The design of drug release in modified release multiparticulate solid dosage form is deliberately changed from that of a conventional immediate-release solid dosage form to achieve a desired therapeutic effect by even distribution of multiparticulates in the gastro-intestinal (GI) tract and better patient compliance by less GI irritation and low risk of dose dumping. Modified release multiparticulate dosage forms also offer better flow properties, enhance of drug dissolution and ease of coating. In this invention, modified release multiparticulate dosage form of metoprolol succinate was prepared by wet granulation, extrusion and spheronization, drug layering, sub coating, controlled release coating and spray congealing. These controlled release pellets of metoprolol succinate with other excipients were compressed into a tablet. The above formulation was evaluated for chemical parameters like assay and in-vitro drug release study.
Loading....